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Due to the multiplicity in medicinal formula and method of refinement, ample amount of case information files are needed in order to establish the mechanisms of ADR in herbal medicine. The Taiwan Adverse Drug Reaction Reporting System (TADRRS) for Herbal Medicine was established at the Center for Traditional Chinese Medicine, Chang-Gung Memorial Hospital in the end of 2001. The reporting system consists of regional reporting centers and five main reporting hospitals, and follows a systematic flow chart with standardized format for filing of reports. ADR report training courses are provided at the local training centers, and information web-sites are established for educational purposes. The main objective of the TADRRS is to receive reports from the public and healthcare workers, so that proper research and evaluation can be executed. The system will help to create a valuable database along with a group of experts on ADR in herbal medicine. By the end of November 2003, we have received a total of 160 reports, 86 from Chinese medical hospitals, 64 from clinical trials, and 10 from media reports. Among the 74 cases reported in 2003, 51 are associated with Chinese medicine, 14 with folk medicine, 4 with acupuncture, 18 with herbal misuse by the patient himself, 13 with physician malpractice, 35 with clinical trials, and 16 with concurrent use of Chinese medicine and western medicine. 11 of these reported cases are attributed to a single factor, but many of these reported cases are not (49 of these reported cases can be attributed to 2 factors, and 14 to more than 3 factors). Manifestations of ADR include vomiting, hematuria, diarrhea, abdominal pain, palpitation , vexation and agitation, insomnia, abnormalities of the menstral cycle, lip tremor, cyanosis, fever, fatigue, headache, delirium, impaired consciousness, gum bleeding, hypoglycemia, nasal congestion, melanosis coli, oral ulcer, impaired liver function, impaired hemopoiesis, increased urination, nosebleed, melena, and duodenal ulcer. 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